Activated EGFR (epidermal growth factor receptor) undergoes ESCRT (endosomal sorting complex required for transport)-mediated sorting on to ILVs (intraluminal vesicles) of endosomes before degradation in the lysosome. Sorting of endocytosed EGFR on to ILVs removes the catalytic domain of the EGFR from the cytoplasm, resulting in termination of receptor signalling. EGFR signalling is also subject to down-regulation through receptor dephosphorylation by the ER (endoplasmic reticulum)-localized PTP1B (protein tyrosine phosphatase 1B). PTP1B on the cytoplasmic face of the ER interacts with endocytosed EGFR via direct membrane contacts sites between the ER and endosomes. In the present paper, we review the relationship between ER–endosome membrane contact sites and ILV formation, and their potential role in the regulation of EGFR sorting on to ILVs, through PTP1B-mediated dephosphorylation of both EGFR and components of the ESCRT machinery.
Skip Nav Destination
Article navigation
April 2012
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
March 21 2012
The relationship between ER–multivesicular body membrane contacts and the ESCRT machinery
Emily R. Eden;
Emily R. Eden
*UCL Institute of Ophthalmology, University College London, 11–43 Bath Street, London EC1V 9EL, U.K.
Search for other works by this author on:
Thomas Burgoyne;
Thomas Burgoyne
*UCL Institute of Ophthalmology, University College London, 11–43 Bath Street, London EC1V 9EL, U.K.
Search for other works by this author on:
James R. Edgar;
James R. Edgar
*UCL Institute of Ophthalmology, University College London, 11–43 Bath Street, London EC1V 9EL, U.K.
Search for other works by this author on:
Alexander Sorkin;
Alexander Sorkin
†Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, U.S.A.
Search for other works by this author on:
Clare E. Futter
Clare E. Futter
1
*UCL Institute of Ophthalmology, University College London, 11–43 Bath Street, London EC1V 9EL, U.K.
1To whom correspondence should be addressed (emailc.futter@ucl.ac.uk).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
December 22 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (2): 464–468.
Article history
Received:
December 22 2011
Citation
Emily R. Eden, Thomas Burgoyne, James R. Edgar, Alexander Sorkin, Clare E. Futter; The relationship between ER–multivesicular body membrane contacts and the ESCRT machinery. Biochem Soc Trans 1 April 2012; 40 (2): 464–468. doi: https://doi.org/10.1042/BST20110774
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.