The study of IE (immediate-early) gene activation mechanisms has provided numerous paradigms for how transcription is controlled in response to extracellular signalling. Many of the findings have been derived from investigating one of the IE genes, FOS, and the models extrapolated to regulatory mechanisms for other IE genes. However, whereas the overall principles of activation appear similar, recent evidence suggests that the underlying mechanistic details may differ depending on cell type, cellular stimulus and IE gene under investigation. In the present paper, we review recent advances in our understanding of IE gene transcription, chiefly focusing on FOS and its activation by ERK (extracellular-signal-regulated kinase) MAPK (mitogen-activated protein kinase) pathway signalling. We highlight important fundamental regulatory principles, but also illustrate the gaps in our current knowledge and the potential danger in making assumptions based on extrapolation from disparate studies.
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February 2012
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Conference Article|
January 19 2012
Immediate-early gene activation by the MAPK pathways: what do and don't we know?
Amanda O'Donnell;
Amanda O'Donnell
1Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
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Zaneta Odrowaz;
Zaneta Odrowaz
1Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
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Andrew D. Sharrocks
Andrew D. Sharrocks
1
1Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.
1To whom correspondence should be addressed (email a.d.sharrocks@manchester.ac.uk).
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Publisher: Portland Press Ltd
Received:
June 20 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (1): 58–66.
Article history
Received:
June 20 2011
Citation
Amanda O'Donnell, Zaneta Odrowaz, Andrew D. Sharrocks; Immediate-early gene activation by the MAPK pathways: what do and don't we know?. Biochem Soc Trans 1 February 2012; 40 (1): 58–66. doi: https://doi.org/10.1042/BST20110636
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