Stringent regulation of biochemical signalling pathways involves feedback and feedforward loops, which underlie robust cellular responses to external stimuli. Regulation occurs in all horizontal layers of signalling networks, primarily by proteins that mediate internalization of receptor–ligand complexes, dephosphorylation of kinases and their substrates, as well as transcriptional repression. Recent studies have unveiled the role of miRNAs (microRNAs), post-transcriptional regulators that control mRNA stability, as key modulators of signal propagation. By acting as genetic switches or fine-tuners, miRNAs can directly and multiply regulate cellular outcomes in response to diverse extracellular signals. Conversely, signalling networks temporally control stability, biogenesis and abundance of miRNAs, by regulating layers of the miRNA biogenesis pathway. In the present mini-review, we use a set of examples to illustrate the extensive interdependence between miRNAs and signalling networks.
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February 2012
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Conference Article|
January 19 2012
Regulation of signalling by microRNAs
Roi Avraham;
Roi Avraham
1Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
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Yosef Yarden
Yosef Yarden
1
1Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
1To whom correspondence should be addressed (email yosef.yarden@weizmann.ac.il).
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Publisher: Portland Press Ltd
Received:
June 15 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (1): 26–30.
Article history
Received:
June 15 2011
Citation
Roi Avraham, Yosef Yarden; Regulation of signalling by microRNAs. Biochem Soc Trans 1 February 2012; 40 (1): 26–30. doi: https://doi.org/10.1042/BST20110623
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