The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the ‘hallmarks of cancer’ as a framework and consider how this pathway is deregulated. As well as playing a key role in endothelial cell survival and tubular morphogenesis during tumour neovascularization, ERK5 is also emerging as a regulator of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145. Together, these finding underscore the case for further investigation into understanding the role of ERK5 in cancer.
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February 2012
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Conference Article|
January 19 2012
ERK5 and its role in tumour development
Pamela A. Lochhead;
Pamela A. Lochhead
1
1Laboratory of Signalling and Cell Fate, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
1To whom correspondence should be addressed (email pamela.lochhead@babraham.ac.uk).
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Rebecca Gilley;
Rebecca Gilley
1Laboratory of Signalling and Cell Fate, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
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Simon J. Cook
Simon J. Cook
1Laboratory of Signalling and Cell Fate, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
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Publisher: Portland Press Ltd
Received:
July 25 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (1): 251–256.
Article history
Received:
July 25 2011
Citation
Pamela A. Lochhead, Rebecca Gilley, Simon J. Cook; ERK5 and its role in tumour development. Biochem Soc Trans 1 February 2012; 40 (1): 251–256. doi: https://doi.org/10.1042/BST20110663
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