Regulation of store-operated calcium entry during cell division

Store-operate Ca²⁺ channels gate Ca²⁺ entry into the cytoplasm in response to the depletion of Ca²⁺ from endoplasmic reticulum Ca²⁺ stores. The major molecular components of store-operated Ca²⁺ entry are STIM (stromal-interacting molecule) 1 (and in some instances STIM2) that serves as the endoplasmic reticulum Ca²⁺ sensor, and Orai (Orai1, Orai2 and Orai3) which function as pore-forming subunits of the store-operated channel. It has been known for some time that store-operated Ca²⁺ entry is shut down during cell division. Recent work has revealed complex mechanisms regulating the functions and locations of both STIM1 and Orai1 in dividing cells.