Interest in the glycerophosphoinositols has been increasing recently, on the basis of their biological activities. The cellular metabolism of these water-soluble bioactive phosphoinositide metabolites has been clarified, with the identification of the specific enzyme involved in their synthesis, PLA2IVα (phospholipase A2 IVα), and the definition of their phosphodiesterase-based catabolism, and thus inactivation. The functional roles and mechanisms of action of these compounds have been investigated in different cellular contexts. This has led to their definition in the control of various cell functions, such as cell proliferation in the thyroid and actin cytoskeleton organization in fibroblasts and lymphocytes. Roles for the glycerophosphoinositols in immune and inflammatory responses are also being defined. In addition to these physiological functions, the glycerophosphoinositols have potential anti-metastatic activities that should lead to their pharmacological exploitation.
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February 2012
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Conference Article|
January 19 2012
The glycerophosphoinositols and their cellular functions
Daniela Corda;
Daniela Corda
1
*Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
1To whom correspondence should be addressed (email d.corda@ibp.cnr.it).
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Pasquale Zizza;
Pasquale Zizza
*Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
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Alessia Varone;
Alessia Varone
*Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
†Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
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Karol S. Bruzik;
Karol S. Bruzik
‡Department of Medicinal Chemistry and Pharmacognosy, The University of Illinois at Chicago, 833 S. Wood St., Chicago, IL 60612, U.S.A.
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Stefania Mariggiò
Stefania Mariggiò
*Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
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Publisher: Portland Press Ltd
Received:
August 02 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem Soc Trans (2012) 40 (1): 101–107.
Article history
Received:
August 02 2011
Citation
Daniela Corda, Pasquale Zizza, Alessia Varone, Karol S. Bruzik, Stefania Mariggiò; The glycerophosphoinositols and their cellular functions. Biochem Soc Trans 1 February 2012; 40 (1): 101–107. doi: https://doi.org/10.1042/BST20110679
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