Pseudomonas pseudoalcaligenes CECT5344 can be used in cyanide bioremediation processes because it grows at pH 9.5 using 2.0 mM cyanide at the sole nitrogen source. Cyanide strongly binds to metals creating iron-deprivation conditions. The bacterium responds to the presence of cyanide by inducing several processes such as siderophore synthesis for iron capture, cyanide-insensitive respiration system and defence mechanisms against oxidative stress. Since high concentrations of cyanide cause iron deficiency and because iron is an essential nutrient, bacterial growth in the presence of cyanide requires an efficient iron uptake. Fur is a global transcription factor that regulates a diversity of biological processes such as iron homoeostasis, TCA (tricarboxylic acid) cycle metabolism and oxidative stress response. Fur's regulation of iron uptake and storage genes should play a significant role in the lives of these bacteria. In the present review, current knowledge of Fur is summarized.
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December 2011
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Conference Article|
November 21 2011
Role of Fur on cyanide tolerance of Pseudomonas pseudoalcaligenes CECT5344
Gracia Becerra;
Gracia Becerra
1Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Avda. de la Universidad s/n, 10003 Cáceres, Spain
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Rafael Blasco;
Rafael Blasco
1Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Avda. de la Universidad s/n, 10003 Cáceres, Spain
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Alberto Quesada;
Alberto Quesada
1Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Avda. de la Universidad s/n, 10003 Cáceres, Spain
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Faustino Merchán;
Faustino Merchán
1Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Avda. de la Universidad s/n, 10003 Cáceres, Spain
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M. Isabel Igeño
M. Isabel Igeño
1
1Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Avda. de la Universidad s/n, 10003 Cáceres, Spain
1To whom correspondence should be addressed (email migeno@unex.es).
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Publisher: Portland Press Ltd
Received:
August 17 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1854–1858.
Article history
Received:
August 17 2011
Citation
Gracia Becerra, Rafael Blasco, Alberto Quesada, Faustino Merchán, M. Isabel Igeño; Role of Fur on cyanide tolerance of Pseudomonas pseudoalcaligenes CECT5344. Biochem Soc Trans 1 December 2011; 39 (6): 1854–1858. doi: https://doi.org/10.1042/BST20110706
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