Aging was once thought to be the result of a general deterioration of tissues as opposed to their being under regulatory control. However, investigations in a number of model organisms have illustrated that aspects of aging are controlled by genetic mechanisms and are potentially manipulable, suggesting the possibility of treatment for age-related disorders. Reproductive decline is one aspect of aging. In model organisms and humans of both sexes, increasing age is associated with both a decline in the number of progeny and an increased incidence of defects. The cellular mechanisms of reproductive aging are not well understood, although a number of factors, both intrinsic and extrinsic to an organism's germline, may contribute to aging phenotypes. Recent work in a variety of organisms suggests that nuclear organization and nuclear envelope proteins may play a role in these processes.
Skip Nav Destination
Article navigation
December 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 21 2011
Reproductive aging: insights from model organisms
Alice L. Ye;
Alice L. Ye
1Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, U.S.A.
Search for other works by this author on:
Needhi Bhalla
Needhi Bhalla
1
1Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, U.S.A.
1To whom correspondence should be addressed (email nbhalla@ucsc.edu).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 15 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1770–1774.
Article history
Received:
August 15 2011
Citation
Alice L. Ye, Needhi Bhalla; Reproductive aging: insights from model organisms. Biochem Soc Trans 1 December 2011; 39 (6): 1770–1774. doi: https://doi.org/10.1042/BST20110694
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.