The fifth U.K. meeting on nuclear envelope disease and chromatin brought together international experts from across the field of nuclear envelope biology to discuss the advancements in a class of tissue-specific degenerative diseases called the laminopathies. Clinically, these range from relatively mild fat-wasting disorders to the severe premature aging condition known as Hutchinson–Gilford progeria syndrome. Since the first association of the nuclear envelope with human inherited disease in 1994, there has been an exponential increase in an unexpected variety of functions associated with nuclear envelope proteins, ranging from mechanical support and nucleocytoskeletal connections to regulation of chromatin organization and gene expression. This Biochemical Society Focused Meeting reinforced the functional complexity of nuclear-associated diseases, revealed new avenues to be investigated and highlighted the signalling pathways suitable as therapeutic targets.
Skip Nav Destination
Article navigation
December 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 21 2011
Nuclear Envelope Disease and Chromatin Organization
Juliet A. Ellis;
Juliet A. Ellis
1
*The Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, U.K.
1To whom correspondence should be addressed (email juliet.ellis@kcl.ac.uk).
Search for other works by this author on:
Sue Shackleton
Sue Shackleton
†Department of Biochemistry, Henry Wellcome Building, University of Leicester, Leicester LE1 9HN, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 14 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1683–1686.
Article history
Received:
September 14 2011
Citation
Juliet A. Ellis, Sue Shackleton; Nuclear Envelope Disease and Chromatin Organization. Biochem Soc Trans 1 December 2011; 39 (6): 1683–1686. doi: https://doi.org/10.1042/BST20110744
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.