Therapeutic angiogenesis is an attractive strategy to treat patients suffering from peripheral or coronary artery disease. VEGF (vascular endothelial growth factor-A) is the fundamental factor controlling vascular growth in both development and postnatal life. The interplay between the VEGF and Notch signalling pathway has been recently found to regulate the morphogenic events leading to the growth of new vessels by sprouting. Angiogenesis can also take place by an alternative process, i.e. intussusception or vascular splitting. However, little is known about its role in therapeutic angiogenesis and its molecular regulation. In the present article, we briefly review how VEGF dose determines the induction of normal or aberrant angiogenesis and the molecular regulation of sprouting angiogenesis by Notch signalling, and compare this process with intussusception.
Skip Nav Destination
Article navigation
December 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 21 2011
To sprout or to split? VEGF, Notch and vascular morphogenesis
Roberto Gianni-Barrera;
Roberto Gianni-Barrera
1
1Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland
1Correspondence may be addressed to either of these authors (email giannibarrerar@uhbs.ch or abanfi@uhbs.ch).
Search for other works by this author on:
Marianna Trani;
Marianna Trani
1Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland
Search for other works by this author on:
Silvia Reginato;
Silvia Reginato
1Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland
Search for other works by this author on:
Andrea Banfi
Andrea Banfi
1
1Cell and Gene Therapy, Department of Biomedicine and Department of Surgery, Basel University Hospital, Hebelstrasse 20, Basel, CH-4031, Switzerland
1Correspondence may be addressed to either of these authors (email giannibarrerar@uhbs.ch or abanfi@uhbs.ch).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 12 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1644–1648.
Article history
Received:
July 12 2011
Citation
Roberto Gianni-Barrera, Marianna Trani, Silvia Reginato, Andrea Banfi; To sprout or to split? VEGF, Notch and vascular morphogenesis. Biochem Soc Trans 1 December 2011; 39 (6): 1644–1648. doi: https://doi.org/10.1042/BST20110650
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.