Capillaries have been recognized for over a century as one of the most important components in regulating tissue oxygen transport, and their formation or angiogenesis a pivotal element of tissue remodelling during development and adaptation. Clinical interest stems from observations that both excessive and inadequate vascular growth plays a major role in human diseases, and novel developments in treatments for cancer and eye disease increasingly rely on anti-angiogenic therapies. Although the discovery of VEGF (vascular endothelial growth factor) provided the first clue for specificity of signalling in endothelial cell activation, understanding the integrative response that drives angiogenesis requires a much broader perspective. The Advances in the Cellular and Molecular Biology of Angiogenesis meeting brought together researchers at the forefront of this rapidly moving field to provide an update on current understanding, and the most recent insights into molecular and cellular mechanisms of vascular growth. The plenary lecture highlighted the integrative nature of the angiogenic process, whereas invited contributions from basic and clinician scientists described fundamental mechanisms and disease-associated issues of blood vessel formation, grouped under a number of themes to aid discussion. These articles will appeal to academic, clinical and pharmaceutical scientists interested in the molecular and cellular basis of angiogenesis, their modulation or dysfunction in human diseases, and application of these findings towards translational medicine.
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Conference Article|
November 21 2011
Advances in the Cellular and Molecular Biology of Angiogenesis
Stuart Egginton;
Stuart Egginton
1
*Centre for Cardiovascular Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
1Correspondence may be addressed to either author (email s.egginton@bham.ac.uk or r.bicknell@bham.ac.uk).
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Roy Bicknell
Roy Bicknell
1
†School of Cancer Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
1Correspondence may be addressed to either author (email s.egginton@bham.ac.uk or r.bicknell@bham.ac.uk).
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Publisher: Portland Press Ltd
Received:
September 30 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Article history
Received:
September 30 2011
Citation
Stuart Egginton, Roy Bicknell; Advances in the Cellular and Molecular Biology of Angiogenesis. Biochem Soc Trans 1 December 2011; 39 (6): 1551–1555. doi: https://doi.org/10.1042/BST20110749
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