The baker's yeast, Saccharomyces cerevisiae, is also capable of undergoing programmed cell death or apoptosis, for example in response to viral infection as well as during chronological and replicative aging. Intrinsically, programmed cell death in yeast can be induced by, for example, H2O2, acetic acid or the mating-type pheromone. A number of evolutionarily conserved apoptosis-regulatory proteins have been identified in yeast, one of which is the HtrA (high-temperature requirement A)-like serine protease Nma111p (Nma is nuclear mediator of apoptosis). Nma111p is a nuclear serine protease of the HtrA family, which targets Bir1p, the only known inhibitor-of-apoptosis protein in yeast. Nma111p mediates apoptosis in a serine-protease-dependent manner and exhibits its activity exclusively in the nucleus. How the activity of Nma111p is regulated has remained largely elusive, but some evidence points to a control by phosphorylation. Current knowledge of Nma111p's function in apoptosis will be discussed in the present review.
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Conference Article|
September 21 2011
Nma111p, the pro-apoptotic HtrA-like nuclear serine protease in Saccharomyces cerevisiae: a short survey
Birthe Fahrenkrog
Birthe Fahrenkrog
1
1Institute of Molecular Biology and Medicine, Université Libre de Bruxelles, Rue Prof. Jeener et Brachet 12, 6041 Charleroi, Belgium
1email bfahrenk@ulb.ac.be.
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Publisher: Portland Press Ltd
Received:
June 17 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1499–1501.
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Received:
June 17 2011
Citation
Birthe Fahrenkrog; Nma111p, the pro-apoptotic HtrA-like nuclear serine protease in Saccharomyces cerevisiae: a short survey. Biochem Soc Trans 1 October 2011; 39 (5): 1499–1501. doi: https://doi.org/10.1042/BST0391499
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