Vigorous exercise is associated with oxidative stress, a state that involves modifications to bodily molecules due to release of pro-oxidant species. Assessment of such modifications provides non-specific measures of oxidative stress in human tissues and blood, including circulating lymphocytes. Lymphocytes are a very heterogeneous group of white blood cells, consisting of subtypes that have different functions in immunity. Importantly, exercise drastically changes the lymphocyte composition in blood by increasing the numbers of some subsets, while leaving other cells unaffected. This fact may imply that observed changes in oxidative stress markers are confounded by changes in lymphocyte composition. For example, lymphocyte subsets may differ in exposure to oxidative stress because of subset differences in cell division and the acquisition of cytotoxic effector functions. The aim of the present review is to raise awareness of interpretational issues related to the assessment of oxidative stress in lymphocytes with exercise and to address the relevance of lymphocyte subset phenotyping in these contexts.
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October 2011
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Conference Article|
September 21 2011
Measurement of exercise-induced oxidative stress in lymphocytes
James E. Turner;
*Clinical Immunology, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
1To whom correspondence should be addressed (email j.e.turner@bham.ac.uk).
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Jos A. Bosch;
Jos A. Bosch
†School of Sport and Exercise Science, College of Life and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
‡Mannhein Institute of Public Health, Social and Preventive Medicine (MIPH), University of Heidelberg, D-69120 Heidelberg, Germany
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Sarah Aldred
Sarah Aldred
†School of Sport and Exercise Science, College of Life and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
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Publisher: Portland Press Ltd
Received:
May 26 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1299–1304.
Article history
Received:
May 26 2011
Citation
James E. Turner, Jos A. Bosch, Sarah Aldred; Measurement of exercise-induced oxidative stress in lymphocytes. Biochem Soc Trans 1 October 2011; 39 (5): 1299–1304. doi: https://doi.org/10.1042/BST0391299
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