Considerable evidence exists for oxidative damage to extracellular materials during multiple human pathologies. Unlike cells, the extracellular compartment of most biological tissues is less well protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due to slow turnover and/or poor repair. The nature and consequences of damage to ECM (extracellular matrix) are poorly understood, despite the growing realization that changes in matrix structure not only have structural consequences, but also play a key role in the regulation of cellular adhesion, proliferation, migration and cell signalling. The ECM also plays a key role in cytokine and growth factor binding, and matrix modifications would therefore be expected to alter these parameters. In the present study, we review mechanisms of oxidative damage to ECM, resulting changes in matrix structure and how this affects cellular behaviour. The role of such damage in the development and progression of inflammatory diseases is also discussed with particular reference to cardiovascular disease.
Skip Nav Destination
Article navigation
October 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
September 21 2011
Mechanisms and consequences of oxidative damage to extracellular matrix
Eleanor C. Kennett;
Eleanor C. Kennett
*The Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia
Search for other works by this author on:
Christine Y. Chuang;
Christine Y. Chuang
*The Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia
†Graduate School of Biomedical Engineering, University of New South Wales, Kensington, NSW 2052, Australia
Search for other works by this author on:
Georg Degendorfer;
Georg Degendorfer
*The Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia
Search for other works by this author on:
John M. Whitelock;
John M. Whitelock
†Graduate School of Biomedical Engineering, University of New South Wales, Kensington, NSW 2052, Australia
Search for other works by this author on:
Michael J. Davies
Michael J. Davies
1
*The Heart Research Institute, 7 Eliza Street, Newtown, NSW 2042, Australia
‡Faculty of Medicine, University of Sydney, Sydney, NSW 2006, Australia
1To whom correspondence should be addressed (email daviesm@hri.org.au).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 17 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1279–1287.
Article history
Received:
April 17 2011
Citation
Eleanor C. Kennett, Christine Y. Chuang, Georg Degendorfer, John M. Whitelock, Michael J. Davies; Mechanisms and consequences of oxidative damage to extracellular matrix. Biochem Soc Trans 1 October 2011; 39 (5): 1279–1287. doi: https://doi.org/10.1042/BST0391279
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.