RNA localization coupled to translational repression is a general mechanism for creating structural and functional asymmetry within the cell. While there are many possible ways to target an mRNA to its destination, a large fraction of the studied transcripts undertake active transport mediated by cytoskeletal elements (microtubules and actin filaments) and associated mechanoenzymes. Among the best-studied model systems of RNA localization are the oocyte and the early embryo of Drosophila melanogaster, for which many well-characterized tools have been developed to study this cell biological phenomenon in a dynamic, developing system in its in vivo context. In the present paper, we review the current evidence and models explaining the different modes of RNA localization that depend on active transport within cells.
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October 2011
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Conference Article|
September 21 2011
Microtubule-based motor-mediated mRNA localization in Drosophila oocytes and embryos
Imre Gaspar
Imre Gaspar
1
1EMBL Heidelberg, Developmental Biology Unit, D-69117 Heidelberg, Germany
1email imre.gaspar@embl.de
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Publisher: Portland Press Ltd
Received:
May 13 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1197–1201.
Article history
Received:
May 13 2011
Citation
Imre Gaspar; Microtubule-based motor-mediated mRNA localization in Drosophila oocytes and embryos. Biochem Soc Trans 1 October 2011; 39 (5): 1197–1201. doi: https://doi.org/10.1042/BST0391197
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