Myosins-I are widely expressed actin-dependent motors which bear a phospholipid-binding domain. In addition, some members of the family can trigger Arp2/3 complex (actin-related protein 2/3 complex)-dependent actin polymerization. In the early 1990s, the development of powerful genetic tools in protozoa and mammals and discovery of these motors in yeast allowed the demonstration of their roles in membrane traffic along the endocytic and secretory pathways, in vacuole contraction, in cell motility and in mechanosensing. The powerful yeast genetics has contributed towards dissecting in detail the function and regulation of Saccharomyces cerevisiae myosins-I Myo3 and Myo5 in endocytic budding from the plasma membrane. In the present review, we summarize the evidence, dissecting their exact role in membrane budding and the molecular mechanisms controlling their recruitment and biochemical activities at the endocytic sites.
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October 2011
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Conference Article|
September 21 2011
Function and regulation of Saccharomyces cerevisiae myosins-I in endocytic budding
Jonathan Giblin;
Jonathan Giblin
1
1Instituto de Biología Molecular de Barcelona (IBMB-CSIC) C/Baldiri Reixac 15, 08028 Barcelona, Spain
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Isabel María Fernández-Golbano;
Isabel María Fernández-Golbano
1
1Instituto de Biología Molecular de Barcelona (IBMB-CSIC) C/Baldiri Reixac 15, 08028 Barcelona, Spain
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Fatima-Zahra Idrissi;
Fatima-Zahra Idrissi
1Instituto de Biología Molecular de Barcelona (IBMB-CSIC) C/Baldiri Reixac 15, 08028 Barcelona, Spain
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María Isabel Geli
María Isabel Geli
2
1Instituto de Biología Molecular de Barcelona (IBMB-CSIC) C/Baldiri Reixac 15, 08028 Barcelona, Spain
2To whom correspondence should be addressed (email mgfbmc@ibmb.csic.es).
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Publisher: Portland Press Ltd
Received:
May 02 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1185–1190.
Article history
Received:
May 02 2011
Citation
Jonathan Giblin, Isabel María Fernández-Golbano, Fatima-Zahra Idrissi, María Isabel Geli; Function and regulation of Saccharomyces cerevisiae myosins-I in endocytic budding. Biochem Soc Trans 1 October 2011; 39 (5): 1185–1190. doi: https://doi.org/10.1042/BST0391185
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