Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them. This is well illustrated both by the vectorial transfer of biosynthetic cargo from the endoplasmic reticulum to the Golgi apparatus as well as the sorting of secretory and endocytic cargo in the endosomal system. Roles have been described for dynein and kinesin motors in each of these steps. Cytoplasmic dynein is a highly complex motor comprising multiple subunits that provide functional specialization. The family of human kinesins includes over 40 members. This complexity provides immense functional diversity, yet little is known of the specific requirements and functions of individual motors during discrete membrane trafficking steps. In the present paper, we describe some of the latest findings in this area that seek to define the mechanisms of recruitment and control of activity of microtubule motors in spatial organization and cargo trafficking through the endosomal network.
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Conference Article|
September 21 2011
The role of motor proteins in endosomal sorting
Sylvie D. Hunt;
Sylvie D. Hunt
1Cell Biology Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, U.K.
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David J. Stephens
David J. Stephens
1
1Cell Biology Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, U.K.
1To whom correspondence should be addressed (email david.stephens@bristol.ac.uk).
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Publisher: Portland Press Ltd
Received:
March 30 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (5): 1179–1184.
Article history
Received:
March 30 2011
Citation
Sylvie D. Hunt, David J. Stephens; The role of motor proteins in endosomal sorting. Biochem Soc Trans 1 October 2011; 39 (5): 1179–1184. doi: https://doi.org/10.1042/BST0391179
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