Plasma PLTP (phospholipid-transfer protein) is a member of the lipid transfer/LBP [LPS (lipopolysaccharide)-binding protein] family, which constitutes a superfamily of genes together with the short and long PLUNC (palate, lung and nasal epithelium clone) proteins. Although PLTP was studied initially for its involvement in the metabolism of HDL (high-density lipoproteins) and reverse cholesterol transport (i.e. the metabolic pathway through which cholesterol excess can be transported from peripheral tissues back to the liver for excretion in the bile), it displays a number of additional biological properties. In particular, PLTP can modulate the lipoprotein association and metabolism of LPS that are major components of Gram-negative bacteria. The delayed association of LPS with lipoproteins in PLTP-deficient mice results in a prolonged residence time, in a higher toxicity of LPS aggregates and in a significant increase in LPS-induced mortality as compared with wild-type mice. It suggests that PLTP may play a pivotal role in inflammation and innate immunity through its ability to accelerate the ‘reverse LPS transport’ pathway.
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August 2011
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Conference Article|
July 20 2011
Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’ and innate immunity
Thomas Gautier;
Thomas Gautier
1Inserm Research Center UMR866 – ‘Lipids, Nutrition, Cancer’, University of Burgundy – Medical School, 7 boulevard Jeanne d'Arc, BP87900, 21079 Dijon Cedex, France
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Laurent Lagrost
Laurent Lagrost
1
1Inserm Research Center UMR866 – ‘Lipids, Nutrition, Cancer’, University of Burgundy – Medical School, 7 boulevard Jeanne d'Arc, BP87900, 21079 Dijon Cedex, France
1To whom correspondence should be addressed (email laurent.lagrost@u-bourgogne.fr).
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Publisher: Portland Press Ltd
Received:
March 28 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (4): 984–988.
Article history
Received:
March 28 2011
Citation
Thomas Gautier, Laurent Lagrost; Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’ and innate immunity. Biochem Soc Trans 1 August 2011; 39 (4): 984–988. doi: https://doi.org/10.1042/BST0390984
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