The analysis of the molecular development of AD (Alzheimer's disease) is technically challenging, due to the chronic nature of the disease, the lack of early and definitive clinical diagnosis, and the fact that the abnormal molecular pathology occurs in the brain. Therefore appropriate animal models of AD are essential if we are to dissect the processes leading to molecular pathology, and ultimately to test the efficacy of potential therapies before clinical studies. Unfortunately, there is controversy over the benefits of the available models, the only consensus of opinion being that no perfect model currently exists. The investigation of animal models is extremely costly and time-consuming, therefore researchers tend to focus on one or two models. For scientists entering the AD research field, it can be difficult to identify the most appropriate model for their needs. Therefore the Models of Dementia: the Good, the Bad and the Future Biochemical Society Focused Meeting provided a platform for discussion and debate on the use and limitations of current models, the most appropriate methods for their characterization and identification of the most pressing needs of the field in general.
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August 2011
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Conference Article|
July 20 2011
Models of Dementia: an introductory overview
Lindsay Graham;
Lindsay Graham
1Biomedical Research Institute, University of Dundee, Ninewells Medical School, Dundee DD1 9SY, Scotland, U.K.
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Calum Sutherland
Calum Sutherland
1
1Biomedical Research Institute, University of Dundee, Ninewells Medical School, Dundee DD1 9SY, Scotland, U.K.
1To whom correspondence should be addressed (email c.d.sutherland@dundee.ac.uk).
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Publisher: Portland Press Ltd
Received:
May 13 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (4): 851–856.
Article history
Received:
May 13 2011
Citation
Lindsay Graham, Calum Sutherland; Models of Dementia: an introductory overview. Biochem Soc Trans 1 August 2011; 39 (4): 851–856. doi: https://doi.org/10.1042/BST0390851
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