Diarrhoea is a hallmark of intestinal inflammation. The mechanisms operating in acute inflammation of the intestine are well characterized and are related to regulatory changes induced by inflammatory mediators such as prostaglandins, cytokines or reactive oxygen species, along with leakage due to epithelial injury and changes in permeability. In chronic colitis, however, the mechanisms are less well known, but it is generally accepted that both secretory and absorptive processes are inhibited. These disturbances in ionic transport may be viewed as an adaptation to protracted inflammation of the intestine, since prolonged intense secretion may be physiologically unacceptable in the long term. Mechanistically, the changes in transport may be due to adjustments in the regulation of the different processes involved, to broader epithelial alterations or frank damage, or to modulation of the transportome in terms of expression. In the present review, we offer a summary of the existing evidence on the status of the transportome in chronic intestinal inflammation.
Skip Nav Destination
Article navigation
August 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
July 20 2011
Intestinal inflammation and the enterocyte transportome
Isabel Romero-Calvo;
Isabel Romero-Calvo
*Department of Biochemistry and Molecular Biology II, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
Search for other works by this author on:
Cristina Mascaraque;
Cristina Mascaraque
†Department of Pharmacology, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
Search for other works by this author on:
Antonio Zarzuelo;
Antonio Zarzuelo
†Department of Pharmacology, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
Search for other works by this author on:
María Dolores Suárez;
María Dolores Suárez
*Department of Biochemistry and Molecular Biology II, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
Search for other works by this author on:
Olga Martínez-Augustin;
Olga Martínez-Augustin
*Department of Biochemistry and Molecular Biology II, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
Search for other works by this author on:
Fermín Sánchez de Medina
Fermín Sánchez de Medina
1
†Department of Pharmacology, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
1To whom correspondence should be addressed (email fsanchez@ugr.es).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 18 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (4): 1096–1101.
Article history
Received:
March 18 2011
Citation
Isabel Romero-Calvo, Cristina Mascaraque, Antonio Zarzuelo, María Dolores Suárez, Olga Martínez-Augustin, Fermín Sánchez de Medina; Intestinal inflammation and the enterocyte transportome. Biochem Soc Trans 1 August 2011; 39 (4): 1096–1101. doi: https://doi.org/10.1042/BST0391096
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.