Integrins and growth factor receptors of the ErbB family are involved in the regulation of cellular interactions with the extracellular microenvironment. Cross-talk between these two groups of transmembrane receptors is essential for cellular responses and can be regulated through the formation of multimolecular complexes. Tetraspanins as facilitators and building blocks of specialized microdomains may be involved in this process. In the present study, we demonstrated that, in contrast with previous reports, integrin-mediated adhesion did not stimulate ligand-independent activation of ErbB receptors in epithelial cells. However, integrin-dependent adhesion potentiated ligand-induced activation of EGFR (epidermal growth factor receptor) and ErbB2 and facilitated receptor homo- and hetero-dimerization. The actin cytoskeleton appeared to play a critical role in this phenomenon.
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Conference Article|
March 22 2011
The effect of cell–ECM adhesion on signalling via the ErbB family of growth factor receptors
Xanthippi Alexi;
Xanthippi Alexi
1CRUK Institute for Cancer Studies, School of Cancer Sciences, College for Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
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Fedor Berditchevski;
Fedor Berditchevski
1CRUK Institute for Cancer Studies, School of Cancer Sciences, College for Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
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Elena Odintsova
Elena Odintsova
1
1CRUK Institute for Cancer Studies, School of Cancer Sciences, College for Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, U.K.
1To whom correspondence should be addressed (email e.odintsova@bham.ac.uk).
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Publisher: Portland Press Ltd
Received:
October 28 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (2): 568–573.
Article history
Received:
October 28 2010
Citation
Xanthippi Alexi, Fedor Berditchevski, Elena Odintsova; The effect of cell–ECM adhesion on signalling via the ErbB family of growth factor receptors. Biochem Soc Trans 1 April 2011; 39 (2): 568–573. doi: https://doi.org/10.1042/BST0390568
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