Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase). In the present paper, we describe a novel mechanism whereby CD9 specifically controls localization of talin1, one of the critical regulators of integrin activation, to focal adhesions: CD9-deficiency leads to impaired localization of talin1 to focal adhesions and correlates with increased motility of breast cancer cells.
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April 2011
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Conference Article|
March 22 2011
Tetraspanin CD9 in cell migration
Dale Powner;
Dale Powner
*School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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Petra M. Kopp;
Petra M. Kopp
†Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
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Susan J. Monkley;
Susan J. Monkley
†Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
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David R. Critchley;
David R. Critchley
†Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
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Fedor Berditchevski
Fedor Berditchevski
1
*School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
1To whom correspondence should be addressed (email f.berditchevski@bham.ac.uk).
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Publisher: Portland Press Ltd
Received:
October 29 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (2): 563–567.
Article history
Received:
October 29 2010
Citation
Dale Powner, Petra M. Kopp, Susan J. Monkley, David R. Critchley, Fedor Berditchevski; Tetraspanin CD9 in cell migration. Biochem Soc Trans 1 April 2011; 39 (2): 563–567. doi: https://doi.org/10.1042/BST0390563
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