CD151 is a plasma membrane protein belonging to the tetraspanin superfamily which is expressed on normal cells such as endothelial cells and platelets and frequently overexpressed on cancer cells. It is known to be functionally linked to cancer metastasis. In humans, increased expression of CD151 is indicative of a poor prognosis in different cancer types. Whereas its mechanism of action remains obscure, CD151 was shown to regulate cell motility and adhesion through association with laminin-binding integrins such as α3β1 or α6β4. Several anti-CD151 mAbs (monoclonal antibodies) have been shown to display anti-metastatic activity in vivo. Inhibition of metastasis was not attributed to any effect of these mAbs on tumour cell growth, but was essentially attributed to inhibition of cell motility. We have generated anti-CD151 mAbs which can inhibit the tumoral growth in different xenograft cancer models. As expected, these mAbs were also able to inhibit metastasis in orthotopic cancer models. These data suggest that CD151 could function at multiple cancer stages, including not only metastasis cascade steps, but also earlier steps of primary tumour growth, thus reinforcing the interest of this innovative target in oncology. mAbs targeting CD151 may be of significant interest for cancer biotherapy.
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April 2011
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Conference Article|
March 22 2011
Tetraspanin CD151 as a target for antibody-based cancer immunotherapy
Jean-François Haeuw;
Jean-François Haeuw
1
1Institut de Recherche Pierre Fabre, Centre d’Immunologie, 5 Avenue Napoléon III, 74160 Saint-Julien-en-Genevois, France
1To whom correspondence should be addressed (email jean.francois.haeuw@pierre-fabre.com).
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Liliane Goetsch;
Liliane Goetsch
1Institut de Recherche Pierre Fabre, Centre d’Immunologie, 5 Avenue Napoléon III, 74160 Saint-Julien-en-Genevois, France
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Christian Bailly;
Christian Bailly
1Institut de Recherche Pierre Fabre, Centre d’Immunologie, 5 Avenue Napoléon III, 74160 Saint-Julien-en-Genevois, France
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Nathalie Corvaia
Nathalie Corvaia
1Institut de Recherche Pierre Fabre, Centre d’Immunologie, 5 Avenue Napoléon III, 74160 Saint-Julien-en-Genevois, France
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Publisher: Portland Press Ltd
Received:
January 24 2011
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (2): 553–558.
Article history
Received:
January 24 2011
Citation
Jean-François Haeuw, Liliane Goetsch, Christian Bailly, Nathalie Corvaia; Tetraspanin CD151 as a target for antibody-based cancer immunotherapy. Biochem Soc Trans 1 April 2011; 39 (2): 553–558. doi: https://doi.org/10.1042/BST0390553
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