The assembly of ribosomal subunits from their individual components (rRNA and ribosomal proteins) requires the assistance of a multitude of factors in order to control and increase the efficiency of the assembly process. GTPases of the TRAFAC (translation-factor-related) class constitute a major type of ribosome-assembly factor in Eukaryota and Bacteria. They are thought to aid the stepwise assembly of ribosomal subunits through a ‘molecular switch’ mechanism that involves conformational changes in response to GTP hydrolysis. Most conserved TRAFAC GTPases are involved in ribosome assembly or other translation-associated processes. They typically interact with ribosomal subunits, but in many cases, the exact role that these GTPases play remains unclear. Previous studies almost exclusively focused on the systems of Bacteria and Eukaryota. Archaea possess several conserved TRAFAC GTPases as well, with some GTPase families being present only in the archaeo–eukaryotic lineage. In the present paper, we review the occurrence of TRAFAC GTPases with translation-associated functions in Archaea.
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February 2011
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Conference Article|
January 19 2011
Assembling the archaeal ribosome: roles for translation-factor-related GTPases
Fabian Blombach;
Fabian Blombach
1
1Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
1To whom correspondence should be addressed (email fabian.blombach@gmail.com).
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Stan J.J. Brouns;
Stan J.J. Brouns
1Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
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John van der Oost
John van der Oost
1Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
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Publisher: Portland Press Ltd
Received:
July 22 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 45–50.
Article history
Received:
July 22 2010
Citation
Fabian Blombach, Stan J.J. Brouns, John van der Oost; Assembling the archaeal ribosome: roles for translation-factor-related GTPases. Biochem Soc Trans 1 February 2011; 39 (1): 45–50. doi: https://doi.org/10.1042/BST0390045
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