PCNA (proliferating-cell nuclear antigen) is a ring-shaped protein that encircles duplex DNA and plays an essential role in many DNA metabolic processes. The PCNA protein interacts with a large number of cellular factors and modulates their enzymatic activities. In the present paper, we summarize the structures, functions and interactions of the archaeal PCNA proteins.

Keywords:
archaeon, DNA interaction, DNA sliding clamp, proliferating-cell nuclear antigen (PCNA), proliferating-cell nuclear antigen-interacting protein box (PIP-box), replication factor C (RFC)
© The Authors Journal compilation © 2011 Biochemical Society
2011
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