In organisms of all three domains of life, a plethora of sRNAs (small regulatory RNAs) exists in addition to the well-known RNAs such as rRNAs, tRNAs and mRNAs. Although sRNAs have been well studied in eukaryotes and in bacteria, the sRNA population in archaea has just recently been identified and only in a few archaeal species. In the present paper, we summarize our current knowledge about sRNAs and their function in the halophilic archaeon Haloferax volcanii. Using two different experimental approaches, 111 intergenic and 38 antisense sRNAs were identified, as well as 42 tRFs (tRNA-derived fragments). Observation of differential expression under various conditions suggests that these sRNAs might be active as regulators in gene expression like their bacterial and eukaryotic counterparts. The severe phenotypes observed upon deletion and overexpression of sRNA genes revealed that sRNAs are involved in, and important for, a variety of biological functions in H. volcanii and possibly other archaea. Investigation of the Haloferax Lsm protein suggests that this protein is involved in the archaeal sRNA pathway.
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February 2011
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Conference Article|
January 19 2011
Regulatory RNAs in Haloferax volcanii
Susan Fischer;
Susan Fischer
*Biology II, Ulm University, 89069 Ulm, Germany
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Juliane Benz;
Juliane Benz
*Biology II, Ulm University, 89069 Ulm, Germany
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Bettina Späth;
Bettina Späth
*Biology II, Ulm University, 89069 Ulm, Germany
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Angelika Jellen-Ritter;
Angelika Jellen-Ritter
*Biology II, Ulm University, 89069 Ulm, Germany
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Ruth Heyer;
Ruth Heyer
*Biology II, Ulm University, 89069 Ulm, Germany
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Marcella Dörr;
Marcella Dörr
*Biology II, Ulm University, 89069 Ulm, Germany
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Lisa-Katharina Maier;
Lisa-Katharina Maier
*Biology II, Ulm University, 89069 Ulm, Germany
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Clemens Menzel-Hobeck;
Clemens Menzel-Hobeck
†Institute of Molecular Biosciences, Goethe-University, 60438 Frankfurt, Germany
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Matthias Lehr;
Matthias Lehr
†Institute of Molecular Biosciences, Goethe-University, 60438 Frankfurt, Germany
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Katharina Jantzer;
Katharina Jantzer
†Institute of Molecular Biosciences, Goethe-University, 60438 Frankfurt, Germany
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Julia Babski;
Julia Babski
†Institute of Molecular Biosciences, Goethe-University, 60438 Frankfurt, Germany
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Jörg Soppa;
Jörg Soppa
†Institute of Molecular Biosciences, Goethe-University, 60438 Frankfurt, Germany
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Anita Marchfelder
Anita Marchfelder
1
*Biology II, Ulm University, 89069 Ulm, Germany
1To whom correspondence should be addressed (email anita.marchfelder@uni-ulm.de).
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Publisher: Portland Press Ltd
Received:
July 22 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 159–162.
Article history
Received:
July 22 2010
Citation
Susan Fischer, Juliane Benz, Bettina Späth, Angelika Jellen-Ritter, Ruth Heyer, Marcella Dörr, Lisa-Katharina Maier, Clemens Menzel-Hobeck, Matthias Lehr, Katharina Jantzer, Julia Babski, Jörg Soppa, Anita Marchfelder; Regulatory RNAs in Haloferax volcanii. Biochem Soc Trans 1 February 2011; 39 (1): 159–162. doi: https://doi.org/10.1042/BST0390159
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