Hel308 is a superfamily 2 helicase/translocase that is conserved throughout archaea and in some eukaryotes for repair of genotoxic lesions such as ICLs (interstrand DNA cross-links). Atomic structures of archaeal Hel308 have allowed mechanistic insights into ATPase and helicase functions, but have also highlighted structures that currently lack a known function, such as an unexpected WH (winged helix) domain. This domain and similar overall protein structural organization was also identified in other superfamily 2 helicases that process RNA molecules in eukaryotes: Brr2, Mtr4 and Prp43p. We survey the structure of Hel308 with regard to its WH domain in particular and its function(s) in maintaining structural integrity of the overall Hel308 ring structure, and possibly during interactions of Hel308 with other proteins and/or forked DNA.
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Conference Article|
January 19 2011
Winged helix domains with unknown function in Hel308 and related helicases
Isabel L. Woodman;
Isabel L. Woodman
1School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, U.K.
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Edward L. Bolt
Edward L. Bolt
1
1School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, U.K.
1To whom correspondence should be addressed (email ed.bolt@nottingham.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 29 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem Soc Trans (2011) 39 (1): 140–144.
Article history
Received:
August 29 2010
Citation
Isabel L. Woodman, Edward L. Bolt; Winged helix domains with unknown function in Hel308 and related helicases. Biochem Soc Trans 1 February 2011; 39 (1): 140–144. doi: https://doi.org/10.1042/BST0390140
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