The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly(A) tail (deadenylation) slows down translation of the mRNA, or prevents it entirely, by inducing mRNA decay. Thus deadenylation plays a crucial role in the post-transcriptional regulation of gene expression, deciding the fate of individual mRNAs. It acts both in basal mRNA turnover, as well as in temporally and spatially regulated translation and decay of specific mRNAs. In the present paper, we discuss mRNA deadenylation in eukaryotes, focusing on the main deadenylase, the Ccr4–Not complex, including its composition, regulation and functional roles.
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December 2010
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Conference Article|
November 24 2010
Cytoplasmic deadenylation: regulation of mRNA fate
Katrin Wiederhold;
Katrin Wiederhold
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K.
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Lori A. Passmore
Lori A. Passmore
1
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K.
1To whom correspondence should be addressed (email passmore@mrc-lmb.cam.ac.uk).
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Publisher: Portland Press Ltd
Received:
June 08 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem Soc Trans (2010) 38 (6): 1531–1536.
Article history
Received:
June 08 2010
Citation
Katrin Wiederhold, Lori A. Passmore; Cytoplasmic deadenylation: regulation of mRNA fate. Biochem Soc Trans 1 December 2010; 38 (6): 1531–1536. doi: https://doi.org/10.1042/BST0381531
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