We used MoCA (Modular Control and Regulation Analysis) to demonstrate in intact beating rat heart that physiological activation of contraction by adrenaline involves the almost perfect parallel activation of both mitochondria and myofibrils by intracellular Ca2+. This explains the perfect homoeostasis of the energetic intermediate PCr (phosphocreatine) in heart. When using drugs specifically stimulating either supply or demand activities, MoCA helped reveal the very specific mode of regulation of heart contraction energetics. Only activation of myofibrils activity (demand), either by increasing intracellular Ca2+ concentration or myofibrils sensitivity to Ca2+, triggers activation of contractile activity. In contrast, the activation of mitochondrial activity (supply) has strictly no effect on contraction, either directly or through PCr changes (intermediate).
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October 2010
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Conference Article|
September 24 2010
System analysis of the effect of various drugs on cardiac contraction energetics
Véronique Deschodt-Arsac;
Véronique Deschodt-Arsac
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
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Guillaume Calmettes;
Guillaume Calmettes
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
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Gilles Gouspillou;
Gilles Gouspillou
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
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Richard Rouland;
Richard Rouland
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
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Eric Thiaudiere;
Eric Thiaudiere
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
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Sylvain Miraux;
Sylvain Miraux
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
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Jean-Michel Franconi;
Jean-Michel Franconi
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
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Philippe Diolez
Philippe Diolez
1
1Résonance Magnétique des Systèmes Biologiques, UMR5536, Centre National de la Recherche Scientifique, Université Victor Segalen, Bordeaux 2, France
1To whom correspondence should be addressed (email Diolez@u-bordeaux2.fr).
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Publisher: Portland Press Ltd
Received:
March 05 2010
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem Soc Trans (2010) 38 (5): 1319–1321.
Article history
Received:
March 05 2010
Citation
Véronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Richard Rouland, Eric Thiaudiere, Sylvain Miraux, Jean-Michel Franconi, Philippe Diolez; System analysis of the effect of various drugs on cardiac contraction energetics. Biochem Soc Trans 1 October 2010; 38 (5): 1319–1321. doi: https://doi.org/10.1042/BST0381319
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