Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their assembly in solution.

Keywords:
complex symmetry, homomer, interaction interface, protein complex, quaternary structure conservation
© The Authors Journal compilation © 2010 Biochemical Society
2010
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