Error-free chromosome segregation during cell division relies on chromosome biorientation and mitotic checkpoint activity. A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles of these kinases in maintaining chromosomal stability.

Keywords:
aneuploidy, chromosome, kinase, kinetochore, mitotic checkpoint, segregation, spindle
© The Authors Journal compilation © 2009 Biochemical Society
2009
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