Cell motility is important for many physiological and pathological processes including organ development, wound healing, cancer metastasis and correct immune responses. In particular, epithelial wound healing is both a medically relevant topic and a common experimental model. Mechanisms underlying generation of a polarized cell and maintenance of a motile phenotype during steady-state migration are not well understood. Polarized trafficking of bulk membrane and cell adhesion molecules has been implicated in regulation of cell motility. The present review focuses on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling.
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October 2009
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Conference Article|
September 21 2009
The role of vesicle trafficking in epithelial cell motility
Sarah J. Fletcher;
Sarah J. Fletcher
1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
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Joshua Z. Rappoport
Joshua Z. Rappoport
1
1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
1To whom any correspondence should be addressed (email J.rappaport@bham.ac.uk).
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Publisher: Portland Press Ltd
Received:
May 29 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (5): 1072–1076.
Article history
Received:
May 29 2009
Citation
Sarah J. Fletcher, Joshua Z. Rappoport; The role of vesicle trafficking in epithelial cell motility. Biochem Soc Trans 1 October 2009; 37 (5): 1072–1076. doi: https://doi.org/10.1042/BST0371072
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