The GTPase dynamin is essential for CME (clathrin-mediated endocytosis), but its exact function and mechanism of action have been controversial. Here, we review findings that have led to the current models for dynamin function, either as a mechanochemical enzyme driving membrane fission or as a regulatory GTPase monitoring rate-limiting steps in CME. However, these models are not mutually exclusive and subsequent studies have provided evidence for both dynamin functions. Recent evidence derived from divergent in vivo and in vitro approaches suggests that dynamin plays a dual role in CME, functioning at early stages as a fidelity monitor to regulate clathrin-coated pit maturation and at later stages to directly catalyse membrane fission and clathrin-coated vesicle formation.
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October 2009
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Conference Article|
September 21 2009
Dissecting dynamin's role in clathrin-mediated endocytosis
Marcel Mettlen;
Marcel Mettlen
1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, U.S.A.
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Thomas Pucadyil;
Thomas Pucadyil
1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, U.S.A.
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Rajesh Ramachandran;
Rajesh Ramachandran
1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, U.S.A.
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Sandra L. Schmid
Sandra L. Schmid
1
1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, U.S.A.
1To whom correspondence should be addressed (email slschmid@scripps.edu).
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Publisher: Portland Press Ltd
Received:
March 04 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (5): 1022–1026.
Article history
Received:
March 04 2009
Citation
Marcel Mettlen, Thomas Pucadyil, Rajesh Ramachandran, Sandra L. Schmid; Dissecting dynamin's role in clathrin-mediated endocytosis. Biochem Soc Trans 1 October 2009; 37 (5): 1022–1026. doi: https://doi.org/10.1042/BST0371022
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