The NHEJ (non-homologous end-joining) pathway is one of the major mechanisms for repairing DSBs (double-strand breaks) that occur in genomic DNA. In common with eukaryotic organisms, many prokaryotes possess a conserved NHEJ apparatus that is essential for the repair of DSBs arising in the stationary phase of the cell cycle. Although the bacterial NHEJ complex is much more minimal than its eukaryotic counterpart, both pathways share a number of common mechanistic features. The relative simplicity of the prokaryotic NHEJ complex makes it a tractable model system for investigating the cellular and molecular mechanisms of DSB repair. The present review describes recent advances in our understanding of prokaryotic end-joining, focusing primarily on biochemical, structural and cellular aspects of the mycobacterial NHEJ repair pathway.
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June 2009
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Conference Article|
May 20 2009
Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway
Nigel C. Brissett;
Nigel C. Brissett
1Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, U.K.
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Aidan J. Doherty
Aidan J. Doherty
1
1Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, U.K.
1To whom correspondence should be addressed (email ajd21@sussex.ac.uk).
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Publisher: Portland Press Ltd
Received:
February 11 2009
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (3): 539–545.
Article history
Received:
February 11 2009
Citation
Nigel C. Brissett, Aidan J. Doherty; Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway. Biochem Soc Trans 1 June 2009; 37 (3): 539–545. doi: https://doi.org/10.1042/BST0370539
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