Cell growth and cell division are coupled to control cell size and this co-ordination is often modulated by the availability of nutrients. In many eukaryotes, TOR (target of rapamycin) signalling is involved in coupling nutrient sensing to cell growth and division controls. Nutrient stress inhibits TOR signalling to advance the timing of cell division and thus leads to continued cell division at reduced cell size. Most changes in the environment stimulate stress-activated MAPK (mitogen-activated protein kinase) signalling pathways. Several MAPKs also have a general role in the control of mitotic onset and cell division. In the present paper, I discuss the interplay between two major signalling pathways, the TOR and the stress MAPK signalling pathways, in controlling mitotic commitment, with the main focus being on fission yeast (Schizosaccharomyces pombe).
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February 2009
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Conference Article|
January 20 2009
TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress
Janni Petersen
Janni Petersen
1
1University of Manchester, Michael Smith Building, Faculty of Life Sciences, Oxford Road, Manchester M13 9PT, U.K.
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Publisher: Portland Press Ltd
Received:
November 18 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 273–277.
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Received:
November 18 2008
Citation
Janni Petersen; TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress. Biochem Soc Trans 1 February 2009; 37 (1): 273–277. doi: https://doi.org/10.1042/BST0370273
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