Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli. mTORC1 signalling regulates several components of the protein synthetic machinery, including initiation and elongation factors, protein kinases which phosphorylate the ribosome and/or translation factors, and the translation of specific mRNAs. However, there are still important gaps in our understanding of the actions of mTORC1 and the relative contributions that different targets of mTORC1 make to the activation of protein synthesis remain to be established.
Skip Nav Destination
Article navigation
February 2009
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
January 20 2009
mTORC1 signalling and mRNA translation
Christopher G. Proud
Christopher G. Proud
1
1School of Biological Sciences, University of Southampton, Southampton SO16 7PX, U.K.
1email C.G.Proud@soton.ac.uk
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 05 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 227–231.
Article history
Received:
September 05 2008
Citation
Christopher G. Proud; mTORC1 signalling and mRNA translation. Biochem Soc Trans 1 February 2009; 37 (1): 227–231. doi: https://doi.org/10.1042/BST0370227
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.