Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved in endosomal trafficking, the genuine function of the protein in this process remains unclear. We have demonstrated recently that Alix and ALG-2 form in the presence of calcium, a complex with apical caspases and with the endocytosed death receptor TNFR1 (tumour necrosis factor α receptor 1), thus suggesting a molecular coupling between endosomes and the cell death machinery.
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February 2009
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Conference Article|
January 20 2009
Alix and ALG-2 make a link between endosomes and neuronal death
Anne-Laure Mahul-Mellier;
Anne-Laure Mahul-Mellier
1
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Flavie Strappazzon;
Flavie Strappazzon
2
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Christine Chatellard-Causse;
Christine Chatellard-Causse
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Béatrice Blot;
Béatrice Blot
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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David Béal;
David Béal
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Sakina Torch;
Sakina Torch
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Fiona Hemming;
Fiona Hemming
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Anne Petiot;
Anne Petiot
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Jean-Marc Verna;
Jean-Marc Verna
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Sandrine Fraboulet;
Sandrine Fraboulet
3
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
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Rémy Sadoul
Rémy Sadoul
4
1INSERM, U836, Equipe 2, Neurodégénérescence et Plasticité, Grenoble, F-38042, France, and Université Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, F-38042, France
4To whom correspondence should be addressed (email remy.sadoul@ujf-grenoble.fr).
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Publisher: Portland Press Ltd
Received:
November 06 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2009 Biochemical Society
2009
Biochem Soc Trans (2009) 37 (1): 200–203.
Article history
Received:
November 06 2008
Citation
Anne-Laure Mahul-Mellier, Flavie Strappazzon, Christine Chatellard-Causse, Béatrice Blot, David Béal, Sakina Torch, Fiona Hemming, Anne Petiot, Jean-Marc Verna, Sandrine Fraboulet, Rémy Sadoul; Alix and ALG-2 make a link between endosomes and neuronal death. Biochem Soc Trans 1 February 2009; 37 (1): 200–203. doi: https://doi.org/10.1042/BST0370200
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