The formation of multivalent complexes of soluble galectins with glycoprotein receptors on the plasma membrane helps to organize glycoprotein assemblies on the surface of the cell. In some cell types, this formation of galectin–glycan lattices or scaffolds is critical for organizing plasma membrane domains, such as lipid rafts, or for targeted delivery of glycoproteins to the apical or basolateral surface. Galectin–glycan lattice formation is also involved in regulating the signalling threshold of some cell-surface glycoproteins, including T-cell receptors and growth factor receptors. Finally, galectin–glycan lattices can determine receptor residency time by inhibiting endocytosis of glycoprotein receptors from the cell surface, thus modulating the magnitude or duration of signalling from the cell surface. This paper reviews recent evidence in vitro and in vivo for critical physiological and cellular functions that are regulated by galectin–glycoprotein interactions.
Skip Nav Destination
Article navigation
December 2008
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 19 2008
Galectin–glycan lattices regulate cell-surface glycoprotein organization and signalling
Omai B. Garner;
Omai B. Garner
1Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
Search for other works by this author on:
Linda G. Baum
Linda G. Baum
1
1Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, U.S.A.
1To whom correspondence should be addressed (email lbaum@mednet.ucla.edu).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 10 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1472–1477.
Article history
Received:
July 10 2008
Citation
Omai B. Garner, Linda G. Baum; Galectin–glycan lattices regulate cell-surface glycoprotein organization and signalling. Biochem Soc Trans 1 December 2008; 36 (6): 1472–1477. doi: https://doi.org/10.1042/BST0361472
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.