Work in the nuclear transport field has led to an incredibly detailed description of protein translocation through the central channel of the nuclear pore complex, yet the mechanism by which nuclear envelope transmembrane proteins reach the inner nuclear membrane after synthesis in the endoplasmic reticulum is still hotly debated. Three different translocation models have gained experimental support: (i) simple lateral diffusion through the nuclear envelope membrane system; (ii) translocation by vesicle fusion events; and (iii) a variation on classical transport mediated by the nuclear pore complex. Although these models appear to be mutually exclusive, in the present paper we argue that they probably all function for different inner nuclear membrane proteins according to their unique characteristics.
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Conference Article|
November 19 2008
Inner nuclear membrane protein transport is mediated by multiple mechanisms
Nikolaj Zuleger;
Nikolaj Zuleger
1The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, U.K.
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Nadia Korfali;
Nadia Korfali
1The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, U.K.
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Eric C. Schirmer
Eric C. Schirmer
1
1The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, U.K.
1To whom correspondence should be addressed (email e.schirmer@ed.ac.uk).
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Publisher: Portland Press Ltd
Received:
July 03 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1373–1377.
Article history
Received:
July 03 2008
Citation
Nikolaj Zuleger, Nadia Korfali, Eric C. Schirmer; Inner nuclear membrane protein transport is mediated by multiple mechanisms. Biochem Soc Trans 1 December 2008; 36 (6): 1373–1377. doi: https://doi.org/10.1042/BST0361373
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