Over the last few years, several novel proteins have been identified that facilitate the physical integration of the nucleus with the cytoplasmic compartment. The majority belong to the evolutionarily conserved KASH [klarsicht/ANC-1 (anchorage 1)/SYNE (synaptic nuclear envelope protein) homology]-domain family, which function primarily as exclusive outer nuclear membrane scaffolds that associate with the cytoskeleton, the centrosome and the motor protein apparatus. In the present paper, we propose a novel model, which may explain why these proteins also determine nuclear architecture. Moreover, we discuss further nuclear membrane-tethering devices, which indicate collectively the presence of specific molecular mechanisms that organize the cytoplasmic–nuclear membrane interface in mammalian cells.
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December 2008
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Conference Article|
November 19 2008
KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope
Maria Schneider;
Maria Schneider
*School of Biological and Biomedical Sciences, University of Durham, South Road, Durham DH1 3LE, U.K.
†Center for Biochemistry and the Center for Molecular Medicine Cologne, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, D50931 Cologne, Germany
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Angelika A. Noegel;
Angelika A. Noegel
†Center for Biochemistry and the Center for Molecular Medicine Cologne, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, D50931 Cologne, Germany
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Iakowos Karakesisoglou
Iakowos Karakesisoglou
1
*School of Biological and Biomedical Sciences, University of Durham, South Road, Durham DH1 3LE, U.K.
1To whom correspondence should be addressed (email iakowos.karakesisoglou@durham.ac.uk).
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Publisher: Portland Press Ltd
Received:
September 09 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1368–1372.
Article history
Received:
September 09 2008
Citation
Maria Schneider, Angelika A. Noegel, Iakowos Karakesisoglou; KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope. Biochem Soc Trans 1 December 2008; 36 (6): 1368–1372. doi: https://doi.org/10.1042/BST0361368
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