In mammalian cells, miRNAs (microRNAs) are the most abundant family of small non-coding RNAs that regulate mRNA translation through the RNA interference pathway. In general, it appears that the major function of miRNAs is in development, differentiation and homoeostasis, which is indicated by studies showing aberrant miRNA expression during the development of cancer. Interestingly, changes in the expression of miR-146a have been implicated in both the development of multiple cancers and in the negative regulation of inflammation induced via the innate immune response. Furthermore, miR-146a expression is driven by the transcription factor NF-κB (nuclear factor κB), which has been implicated as an important causal link between inflammation and carcinogenesis. In the present article, we review the evidence for a role of miR-146a in innate immunity and cancer and assess whether changes in miR-146a might link these two biological responses.
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December 2008
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Conference Article|
November 19 2008
Role of miRNA-146a in the regulation of the innate immune response and cancer
Andrew E. Williams;
Andrew E. Williams
*Biopharmaceutics Research Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London SW3 6LY, U.K.
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Mark M. Perry;
Mark M. Perry
*Biopharmaceutics Research Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London SW3 6LY, U.K.
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Sterghios A. Moschos;
Sterghios A. Moschos
†Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NU, U.K.
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Hanna M. Larner-Svensson;
Hanna M. Larner-Svensson
*Biopharmaceutics Research Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London SW3 6LY, U.K.
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Mark A. Lindsay
Mark A. Lindsay
1
*Biopharmaceutics Research Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London SW3 6LY, U.K.
‡Respiratory Research Group, Wythenshawe Hospital, School of Translational Medicine, University of Manchester, Manchester M23 9LT, U.K.
1To whom correspondence should be addressed (email mark.lindsay@manchester.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 29 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1211–1215.
Article history
Received:
August 29 2008
Citation
Andrew E. Williams, Mark M. Perry, Sterghios A. Moschos, Hanna M. Larner-Svensson, Mark A. Lindsay; Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem Soc Trans 1 December 2008; 36 (6): 1211–1215. doi: https://doi.org/10.1042/BST0361211
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