All types of blood cell of the body are continuously produced by rare pluripotent self-renewing HSCs (haemopoietic stem cells) by a process known as haemopoiesis. This process provides a valuable model for examining how genetic programmes involved in cell differentiation are established, and also how cell-fate specification is altered in leukaemia. Here, we describe examples of how miRNAs (microRNAs) can influence myelopoiesis and how the identification of their target mRNAs has contributed to the understanding of the molecular networks involved in the alternative control between cell growth and differentiation. Ectopic expression and knockdown of specific miRNAs have provided powerful molecular tools able to control the switch between proliferation and differentiation, therefore providing new therapeutic tools for interfering with tumorigenesis.
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December 2008
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Conference Article|
November 19 2008
Role of microRNAs in myeloid differentiation
Alessandro Fatica;
Alessandro Fatica
1
*Department of Genetics and Molecular Biology and Institute Pasteur Cenci-Bolognetti, Sapienza University, Rome 00185, Italy
1To whom correspondence should be addressed (email alessandro.fatica@uniroma1.it).
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Alessandro Rosa;
Alessandro Rosa
2
*Department of Genetics and Molecular Biology and Institute Pasteur Cenci-Bolognetti, Sapienza University, Rome 00185, Italy
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Monica Ballarino;
Monica Ballarino
*Department of Genetics and Molecular Biology and Institute Pasteur Cenci-Bolognetti, Sapienza University, Rome 00185, Italy
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Maria Laura De Marchis;
Maria Laura De Marchis
*Department of Genetics and Molecular Biology and Institute Pasteur Cenci-Bolognetti, Sapienza University, Rome 00185, Italy
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Kasper D. Rasmussen;
Kasper D. Rasmussen
3
*Department of Genetics and Molecular Biology and Institute Pasteur Cenci-Bolognetti, Sapienza University, Rome 00185, Italy
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Irene Bozzoni
Irene Bozzoni
*Department of Genetics and Molecular Biology and Institute Pasteur Cenci-Bolognetti, Sapienza University, Rome 00185, Italy
†Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche, Rome 00185, Italy
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Publisher: Portland Press Ltd
Received:
June 18 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1201–1205.
Article history
Received:
June 18 2008
Citation
Alessandro Fatica, Alessandro Rosa, Monica Ballarino, Maria Laura De Marchis, Kasper D. Rasmussen, Irene Bozzoni; Role of microRNAs in myeloid differentiation. Biochem Soc Trans 1 December 2008; 36 (6): 1201–1205. doi: https://doi.org/10.1042/BST0361201
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