miRNAs (microRNAs) are recently discovered regulators of gene expression. They target mRNAs that contain partially complementary sites to the miRNA. The level of complementarity is different between target site–miRNA pairs, and finding target genes has proved to be a bigger challenge than expected. The present paper reviews the different approaches to predict and experimentally identify genes targeted by miRNAs.

Keywords:
antimir, antagomir, microRNA (miRNA), RNA-induced silencing complex (RISC), target prediction program
© The Authors Journal compilation © 2008 Biochemical Society
2008
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