There is increasing evidence that different transcription units are transcribed together in discrete nuclear structures known as transcription factories. Various new techniques enable us to detect and characterize these structures. We review the latest findings and discuss how they support a model for transcription and chromosome organization.

Keywords:
chromosome conformation capture (3C), chromosome organization, genome organization, locus control region, transcription factory
© The Authors Journal compilation © 2008 Biochemical Society
2008
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