Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction sites whose affinity can be adjusted by conformational masking and phosphorylation.

Keywords:
Dok1, fibronectin, filamin, focal adhesion, integrin, talin
© The Authors Journal compilation © 2008 Biochemical Society
2008
You do not currently have access to this content.