Viral recognition is mediated by different classes of PRRs (pattern-recognition receptors) among which the TLRs (Toll-like receptors) and the RLHs [RIG (retinoic-acid-inducible)-like helicases] play major roles. The detection of PAMPs (pathogen-associated molecular patterns) by these PRRs leads to the initiation of signalling pathways that ultimately result in the activation of transcription factors such as NF-κB (nuclear factor κB) and IRF-3 [IFN (interferon) regulatory factor-3] and IRF-7 and the induction of pro-inflammatory cytokines and type I IFNs. Viruses have evolved a fine-tuned mechanism to evade detection by the immune system or to interfere with the resulting signalling pathways. Here, we discuss viral evasion proteins that specifically interfere with TLR and/or RLH signalling.
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December 2007
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Conference Article|
November 23 2007
An arms race: innate antiviral responses and counteracting viral strategies
M. Schröder;
M. Schröder
1
1Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
1To whom correspondence should be addressed (email schrodem@tcd.ie).
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A.G. Bowie
A.G. Bowie
1Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
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Publisher: Portland Press Ltd
Received:
August 22 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (6): 1512–1514.
Article history
Received:
August 22 2007
Citation
M. Schröder, A.G. Bowie; An arms race: innate antiviral responses and counteracting viral strategies. Biochem Soc Trans 1 December 2007; 35 (6): 1512–1514. doi: https://doi.org/10.1042/BST0351512
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