Drosophila rely primarily on innate immune responses to effectively combat a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of AMPs (antimicrobial peptides) by the fat body, the insect homologue of the mammalian liver. Production of these AMPs is controlled at the level of transcription by two NF-κB (nuclear factor κB) signalling pathways. The Toll pathway is activated by fungal and many Gram-positive bacterial microbes, whereas the IMD (immune deficiency) pathway responds to Gram-negative bacteria and certain Gram-positive bacilli. In the present review, we discuss the mechanisms involved in bacterial recognition, in particular the differential recognition of various types of bacterial PGN (peptidoglycan) by different members of the PGRP (PGN recognition protein) family of receptors.
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December 2007
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Conference Article|
November 23 2007
Peptidoglycan recognition in Drosophila
K. Aggrawal;
K. Aggrawal
1Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01720, U.S.A.
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N. Silverman
N. Silverman
1
1Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01720, U.S.A.
1To whom correspondence should be addressed (email neal.silverman@umassmed.edu).
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Publisher: Portland Press Ltd
Received:
August 17 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (6): 1496–1500.
Article history
Received:
August 17 2007
Citation
K. Aggrawal, N. Silverman; Peptidoglycan recognition in Drosophila. Biochem Soc Trans 1 December 2007; 35 (6): 1496–1500. doi: https://doi.org/10.1042/BST0351496
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