The neutrophil is a crucial early defence against microbial infection, but neutrophilic inflammation can result in devastating acute and chronic inflammatory diseases. In the lungs, the neutrophil is a principal part of the pathology of the acute respiratory distress syndrome, and its activation may also be of substantial importance in chronic obstructive pulmonary disease and some forms of asthma. Induction of neutrophil recruitment in response to microbial attack requires activation of TLR (Toll-like receptor)-based signalling pathways and the concerted actions of multiple cell types, including sentinel cells such as monocytes and macrophages acting together with tissue cell types such as the epithelium or smooth-muscle cell. The present review describes some of these networks and the resulting potential for their targeting in respiratory disease.
Skip Nav Destination
Article navigation
December 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 23 2007
Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease
I. Sabroe;
I. Sabroe
1
1Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, L Floor, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, U.K.
1To whom correspondence should be addressed (email i.sabroe@sheffield.ac.uk).
Search for other works by this author on:
M.K.B. Whyte
M.K.B. Whyte
1Academic Unit of Respiratory Medicine, Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, L Floor, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 29 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (6): 1492–1495.
Article history
Received:
August 29 2007
Citation
I. Sabroe, M.K.B. Whyte; Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease. Biochem Soc Trans 1 December 2007; 35 (6): 1492–1495. doi: https://doi.org/10.1042/BST0351492
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.