Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense bacterial, viral, fungal, protozoan and helminth organisms and activate responses that provide immediate as well as long-term protection for the host. The present article reviews the function and evolution of vertebrate TLRs with an emphasis on the subfamily of receptors comprising human TLR1, 2, 6 and 10. The idea that TLRs undergo strong purifying selection provides the framework for the discussion of single nucleotide polymorphisms, many of which are associated with the incidence of infectious disease.
Skip Nav Destination
Article navigation
December 2007
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
November 23 2007
Genetic polymorphisms within the human Toll-like receptor 2 subfamily
R.I. Tapping;
R.I. Tapping
1
1Department of Microbiology and College of Medicine, University of Illinois at Urbana/Champaign, Urbana, IL 61821, U.S.A.
1To whom correspondence should be addressed (email tapping@life.uiuc.edu).
Search for other works by this author on:
K.O. Omueti;
K.O. Omueti
1Department of Microbiology and College of Medicine, University of Illinois at Urbana/Champaign, Urbana, IL 61821, U.S.A.
Search for other works by this author on:
C.M. Johnson
C.M. Johnson
1Department of Microbiology and College of Medicine, University of Illinois at Urbana/Champaign, Urbana, IL 61821, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 03 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (6): 1445–1448.
Article history
Received:
September 03 2007
Citation
R.I. Tapping, K.O. Omueti, C.M. Johnson; Genetic polymorphisms within the human Toll-like receptor 2 subfamily. Biochem Soc Trans 1 December 2007; 35 (6): 1445–1448. doi: https://doi.org/10.1042/BST0351445
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.