In eukaryotes, gene expression is controlled by a relatively small number of regulators. Post-translational modifications dramatically increase the functional possibilities of those regulators. Modification of many transcription factors and cofactors by SUMO (small ubiquitin-related modifier) correlates, in most cases, with inhibition of transcription. Recent studies suggest a model whereby SUMO conjugation to transcription factors promotes the recruitment of co-repressors through direct protein–protein interaction with the SUMO protein. HDACs (histone deacetylases) are important, but not exclusive, effectors of SUMO-mediated repression. Sp3 (specificity protein 3), a zinc-finger DNA-binding domain transcription factor, has the ability to both activate and repress transcription in a context-dependent manner. SUMOylation regulates the dual nature of Sp3 function. Current data suggest that Sp3 represses transcription in a SUMO-dependent manner but independent of HDACs. Recent studies to identify additional co-repressors associated with SUMO and further investigate regulated activity of Sp3 are providing a deeper understanding of SUMO-dependent mechanisms of transcriptional regulation.
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December 2007
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Conference Article|
November 23 2007
Regulation of the dual-function transcription factor Sp3 by SUMO
A. Valin;
A. Valin
1Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, U.S.A.
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G. Gill
G. Gill
1
1Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, U.S.A.
1To whom correspondence should be addressed (email grace.gill@tufts.edu).
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Publisher: Portland Press Ltd
Received:
June 04 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (6): 1393–1396.
Article history
Received:
June 04 2007
Citation
A. Valin, G. Gill; Regulation of the dual-function transcription factor Sp3 by SUMO. Biochem Soc Trans 1 December 2007; 35 (6): 1393–1396. doi: https://doi.org/10.1042/BST0351393
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